PIM-447 (dihydrochloride)

MedChem Express

PIM-447 (dihydrochloride) [1820565-69-2]

9

1820565-69-2

Research Use Only

99.94

C24H25Cl2F3N4O

513.38

PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis [1] [2] .

O=C(C1=NC(C2=C(F)C=CC=C2F)=C(F)C=C1)NC3=C([C@H]4C[C@@H](N)C[C@@H](C)C4)C=CN=C3.Cl.Cl

2°C to 8°C

12352200