Pimasertib HCl [1236361-78-6]

TargetMol Chemicals

Pimasertib HCl [1236361-78-6]

72

Chemical

Research Use Only

Pimasertib HCl

C15H16ClFIN3O3

467.66

Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types.

3 years

Cl.OC[C@@H](O)CNC(=O)c1ccncc1Nc1ccc(I)cc1F

-20°C

12352200