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PINK1 antibody [N3C3]

GTX107851
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPINK1
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Overview

  • Supplier
    GeneTex
  • Product Name
    PINK1 antibody [N3C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    1.63 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID65018
  • Target name
    PINK1
  • Target description
    PTEN induced kinase 1
  • Target synonyms
    BRPK; PARK6; protein kinase BRPK; PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; serine/threonine-protein kinase PINK1, mitochondrial
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ9BXM7
  • Protein Name
    Serine/threonine-protein kinase PINK1, mitochondrial
  • Scientific Description
    This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq]
  • Reactivity
    Human, Mouse, Rat
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Therapeutic effects of the combination of moderate-intensity endurance training and MitoQ supplementation in rats with isoproterenol-induced myocardial injury: The role of mitochondrial fusion, fission, and mitophagy.
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  • Abnormalities in the SIRT1-SIRT3 axis promote myocardial ischemia-reperfusion injury through ferroptosis caused by silencing the PINK1/Parkin signaling pathway.
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  • Parkin, as a Regulator, Participates in Arsenic Trioxide-Triggered Mitophagy in HeLa Cells. Zhang Z et al., 2022 Jun 20, Curr Issues Mol Biol
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  • The nuclear receptor RORalpha preserves cardiomyocyte mitochondrial function by regulating caveolin-3-mediated mitophagy. Beak JY et al., 2021 Dec, J Biol Chem
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  • Cardiac-specific microRNA-125b deficiency induces perinatal death and cardiac hypertrophy. Chen CY et al., 2021 Jan 27, Sci Rep
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  • Mitochondrial Metabolism as Target of the Neuroprotective Role of Erythropoietin in Parkinsons Disease. Rey F et al., 2021 Jan 15, Antioxidants (Basel)
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  • The potential LXRbeta agonist stigmasterol protects against hypoxia/reoxygenation injury by modulating mitophagy in primary hippocampal neurons. Haque MN et al., 2021 Jan, Phytomedicine
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  • Downregulation of Mitochondrial TSPO Inhibits Mitophagy and Reduces Enucleation during Human Terminal Erythropoiesis. Moras M et al., 2020 Nov 28, Int J Mol Sci
    Read more
  • Astragaloside IV ameliorates diabetic nephropathy by modulating the mitochondrial quality control network. Liu X et al., 2017, PLoS One
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  • NBR1 is dispensable for PARK2-mediated mitophagy regardless of the presence or absence of SQSTM1. Shi J et al., 2015 Oct 29, Cell Death Dis
    Read more