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Pioglitazone HCl

S2046
Selleck Chemicals
CAS Number112529-15-4
Product group Chemicals
Estimated Purity...
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Overview

  • Supplier
    Selleck Chemicals
  • Product Name
    Pioglitazone HCl [112529-15-4]
  • Delivery Days Customer
    9
  • CAS Number
    112529-15-4
  • Certification
    Research Use Only
  • Estimated Purity
    ...
  • Scientific Description
    Pioglitazone HCl (AD-4833, U-72107E) is an inhibitor of cytochrome P450 (CYP)2C8 and CYP3A4 enzymes. Pioglitazone HCl inhibits CYP2C8, CYP3A4 and CYP2C9 with Ki of 1.7 microM, 11.8 microM and 32.1 microM, respectively. Pioglitazone HCl is also a selective peroxisome proliferator-activated receptor-gamma (PPARgamma) agonist with EC50 of 0.93 microM and 0.99 microM for human PPARgamma and mouse PPARgamma, respectively. Pioglitazone HCl inhibits mitochondrial iron uptake, lipid peroxidation, and subsequent ferroptosis.
  • Storage Instruction
    -80°C
  • UNSPSC
    51202000