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ProductsBack/PION antibody

IHC-P analysis of human brain tissue using GTX32001 PION antibody. Working concentration : 5 microg/ml

IHC-P analysis of human brain tissue using GTX32001 PION antibody. Working concentration : 5 microg/ml

IHC-P analysis of human brain tissue using GTX32001 PION antibody. Working concentration : 5 microg/ml

PION antibody

GTX32001

ApplicationsWestern Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin

Product group Antibodies

TargetGSAP

Overview

Supplier
GeneTex
Product Name
PION antibody
Delivery Days Customer
9
Application Supplier Note
WB: 0.25 microg/mL. IHC-P: 5 microg/mL. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Applications
Western Blot, ELISA, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Certification
Research Use Only
Clonality
Polyclonal
Concentration
1 mg/ml
Conjugate
Unconjugated
Gene ID54103
Target name
GSAP
Target description
gamma-secretase activating protein
Target synonyms
PION, gamma-secretase-activating protein, pigeon homolog, protein pigeon homolog
Host
Rabbit
Isotype
IgG
Protein IDA4D1B5
Protein Name
Gamma-secretase-activating protein
Scientific Description
Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010]
Storage Instruction
-20°C or -80°C,2°C to 8°C
UNSPSC
12352203

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