Piperlongumine [20069-09-4]

AdipoGen Life Sciences

Piperlongumine

10

20069-09-4

Research Use Only

>97%

C17H19NO5

317.3

Chemical. CAS: 20069-09-4. Formula: C17H19NO5. MW: 317.3. Isolated from Piper longum roots. Cytotoxic against tumor cell lines. Induces necrosis and apoptosis in cancer cells. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation. Shows significant anxiolytic and antidepressant activities. Promotes adipogenesis of 3T3-L1 cells. Induces in vivo and in vitro mutagenicity in eukaryotic models. Selectively kills cancer cells by targeting the stress response to ROS. Shows in vitro schistosomicidal activity. - Cytotoxic against tumor cell lines [3, 4, 5]. Induces necrosis and apoptosis in cancer cells [5, 9, 12]. Shows anti-platelet aggregation activity possibly by inhibition of cyclooxgenase activity and a decrease in thromboxane A2 formation [4, 6, 10]. Shows significant anxiolytic and antidepressant activities [7]. Promotes adipogenesis of 3T3-L1 cells [8]. Induces in vivo and in vitro mutagenicity in eukaryotic models [11]. Selectively kills cancer cells by targeting the stress response to ROS [12]. Shows in vitro schistosomicidal activity [13]. Selective inhibitor of human immunoproteasome. Targets the beta5i subunit (LMP7) (IC50=15microM) with minimal inhibition of human constitutive proteasome [14].

COC1=CC(\C=C\C(=O)N2CCC=CC2=O)=CC(OC)=C1OC

-20°C,2°C to 8°C

12352200