PK11007

MedChem Express

PK11007 [874146-69-7]

10

874146-69-7

Research Use Only

99.60

C15H11ClFN5O3S2

427.86

PK11007 is a mild thiol alkylator with anticancer activity. PK11007 stabilizes p53 via selective alkylation of two surface-exposed cysteines without compromising its DNA binding activity. PK11007 induces mutant p53 cancer cell death by increasing reactive oxygen species (ROS) levels[1][2].

O=C(C1=NC(S(=O)(CC2=CC=C(F)C=C2)=O)=NC=C1Cl)NC3=NN=C(C)S3

-20°C,2°C to 8°C

12352200