PK11007

AbMole BioScience

PK11007

9

874146-69-7

Chemical

Research Use Only

C15H11ClFN5O3S2

427.86

PK11007 is a mild thiol alkylating agent with anticancer activity that stabilizes p53 through selective alkylation of two surface-exposed cysteines without affecting its DNA-binding activity. It also induces death of mutant p53 cancer cells by increasing reactive oxygen species (ROS) levels.

CC1=NN=C(NC(=O)C2=NC(=NC=C2Cl)[S](=O)(=O)CC3=CC=C(F)C=C3)S1

12352200