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PKA C alpha antibody [N2C3]

GTX104934
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPRKACA
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Overview

  • Supplier
    GeneTex
  • Product Name
    PKA C alpha antibody [N2C3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.8 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5566
  • Target name
    PRKACA
  • Target description
    protein kinase cAMP-activated catalytic subunit alpha
  • Target synonyms
    CAFD1; cAMP-dependent protein kinase catalytic subunit alpha; PKA C-alpha; PKACA; PPNAD4; protein kinase A catalytic subunit; protein kinase, cAMP-dependent, alpha catalytic subunit; protein kinase, cAMP-dependent, catalytic, alpha
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP17612
  • Protein Name
    cAMP-dependent protein kinase catalytic subunit alpha
  • Scientific Description
    cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation.
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  • Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma. Tseng IC et al., 2017 Jun, J Pathol
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  • Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression. Chang CY et al., 2015, Biomed Res Int
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  • Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome. Chu CS et al., 2011 Oct 14, J Biol Chem
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