PKA C alpha antibody [N2C3]
GTX104934
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPRKACA
Overview
- SupplierGeneTex
- Product NamePKA C alpha antibody [N2C3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.8 mg/ml
- ConjugateUnconjugated
- Gene ID5566
- Target namePRKACA
- Target descriptionprotein kinase cAMP-activated catalytic subunit alpha
- Target synonymsCAFD1, PKACA, PPNAD4, cAMP-dependent protein kinase catalytic subunit alpha, PKA C-alpha, protein kinase A catalytic subunit, protein kinase, cAMP-dependent, alpha catalytic subunit, protein kinase, cAMP-dependent, catalytic, alpha
- HostRabbit
- IsotypeIgG
- Protein IDP17612
- Protein NamecAMP-dependent protein kinase catalytic subunit alpha
- Scientific DescriptioncAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Park EJ, Kim HS, Lee DH, et al. Ssu72 phosphatase is essential for thermogenic adaptation by regulating cytosolic translation. Nat Commun. 2023,14(1):1097. doi: 10.1038/s41467-023-36836-yRead this paper
- Tseng IC, Huang WJ, Jhuang YL, et al. Microinsertions in PRKACA cause activation of the protein kinase A pathway in cardiac myxoma. J Pathol. 2017,242(2):134-139. doi: 10.1002/path.4899Read this paper
- Chang CY, Guo HR, Tsai WC, et al. Subchronic Arsenic Exposure Induces Anxiety-Like Behaviors in Normal Mice and Enhances Depression-Like Behaviors in the Chemically Induced Mouse Model of Depression. Biomed Res Int. 2015,2015:159015. doi: 10.1155/2015/159015Read this paper
- Chu CS, Hsu PH, Lo PW, et al. Protein kinase A-mediated serine 35 phosphorylation dissociates histone H1.4 from mitotic chromosome. J Biol Chem. 2011,286(41):35843-35851. doi: 10.1074/jbc.M111.228064Read this paper



![Dot blot analysis of GST and GST-fusion proteins using GTX80257 PKA C alpha antibody [6D2.1] and GTX79895 GST tag antibody [S-tag-05]. The total amount of material spotted on the nitrocellulose membrane is 5 ng/spot. Lane 1 : GST-Akt1 Lane 2 : GST-Akt2 Lane 3 : GST-Akt3 Lane 4 : GST-PKAc alpha Lane 5 : GST-PKAc beta Lane 6 : GST-PKAc gamma Lane 7 : GST-MEK 1 Lane 8 : GST](https://www.genetex.com/upload/website/prouct_img/normal/GTX80257/GTX80257_20191025_AP_008_430_w_23061322_813.webp)

