PKC-IN-4 [2636771-29-2]

MedChem Express

PKC-IN-4 [2636771-29-2]

10

2636771-29-2

Research Use Only

C21H25N5S

379.52

PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 microM. PKC-IN-4 inhibits TNF-alpha induced NF-kappaB activity in vitro. PKC-IN-4 blocks VEGF- and TNFalpha-induced permeability across the retinal vasculature[1].

NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C5=C(S4)CCCC5

12131703