PKM antibody
GTX107977
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPKM
Overview
- SupplierGeneTex
- Product NamePKM antibody
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.13 mg/ml
- ConjugateUnconjugated
- Gene ID5315
- Target namePKM
- Target descriptionpyruvate kinase M1/2
- Target synonymsCTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58, pyruvate kinase PKM, OPA-interacting protein 3, PK, muscle type, cytosolic thyroid hormone-binding protein, epididymis secretory protein Li 30, pyruvate kinase 2/3, pyruvate kinase isozymes M1/M2, pyruvate kinase muscle isozyme, pyruvate kinase, muscle, threonine-protein kinase PKM2, thyroid hormone-binding protein 1, thyroid hormone-binding protein, cytosolic, tumor M2-PK, tyrosine-protein kinase PKM2
- HostRabbit
- IsotypeIgG
- Protein IDP14618
- Protein NamePyruvate kinase PKM
- Scientific DescriptionThe protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Liang YC, Su Q, Liu YJ, et al. Centromere Protein A (CENPA) Regulates Metabolic Reprogramming in the Colon Cancer Cells by Transcriptionally Activating Karyopherin Subunit Alpha 2 (KPNA2). Am J Pathol. 2021,191(12):2117-2132. doi: 10.1016/j.ajpath.2021.08.010Read this paper
- McMahon KA, Stroud DA, Gambin Y, et al. Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. Elife. 2021,10. doi: 10.7554/eLife.61407Read this paper
- Burman A, Kropski JA, Calvi CL, et al. Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein. JCI Insight. 2018,3(16):pii: 99543. doi: 10.1172/jci.insight.99543.Read this paper
- Mattice AMS, MacLean IA, Childers CL, et al. -Characterization of pyruvate kinase from the anoxia tolerant turtle, Trachemys scripta elegans: a potential role for enzyme methylation during metabolic rate depression. PeerJ. 2018,6:e4918. doi: 10.7717/peerj.4918Read this paper
- Chang SJ, Liao EC, Yeo HY, et al. Proteomic investigating the cooperative lethal effect of EGFR and MDM2 inhibitors on ovarian carcinoma. Arch Biochem Biophys. 2018,647:10-32. doi: 10.1016/j.abb.2018.04.004Read this paper
- May EW, Lin ST, Lin CC, et al. Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance. Pharmacol Res. 2014,90:1-17. doi: 10.1016/j.phrs.2014.08.007Read this paper

