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PKM antibody

GTX107977
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPKM
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Overview

  • Supplier
    GeneTex
  • Product Name
    PKM antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. IP: 1:100-1:500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.13 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5315
  • Target name
    PKM
  • Target description
    pyruvate kinase M1/2
  • Target synonyms
    CTHBP, HEL-S-30, OIP3, PK3, PKM2, TCB, THBP1, p58, pyruvate kinase PKM, OPA-interacting protein 3, PK, muscle type, cytosolic thyroid hormone-binding protein, epididymis secretory protein Li 30, pyruvate kinase 2/3, pyruvate kinase isozymes M1/M2, pyruvate kinase muscle isozyme, pyruvate kinase, muscle, threonine-protein kinase PKM2, thyroid hormone-binding protein 1, thyroid hormone-binding protein, cytosolic, tumor M2-PK, tyrosine-protein kinase PKM2
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP14618
  • Protein Name
    Pyruvate kinase PKM
  • Scientific Description
    The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ATP. This protein has been shown to interact with thyroid hormone, and thus may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Liang YC, Su Q, Liu YJ, et al. Centromere Protein A (CENPA) Regulates Metabolic Reprogramming in the Colon Cancer Cells by Transcriptionally Activating Karyopherin Subunit Alpha 2 (KPNA2). Am J Pathol. 2021,191(12):2117-2132. doi: 10.1016/j.ajpath.2021.08.010
    Read this paper
  • McMahon KA, Stroud DA, Gambin Y, et al. Cavin3 released from caveolae interacts with BRCA1 to regulate the cellular stress response. Elife. 2021,10. doi: 10.7554/eLife.61407
    Read this paper
  • Burman A, Kropski JA, Calvi CL, et al. Localized hypoxia links ER stress to lung fibrosis through induction of C/EBP homologous protein. JCI Insight. 2018,3(16):pii: 99543. doi: 10.1172/jci.insight.99543.
    Read this paper
  • Mattice AMS, MacLean IA, Childers CL, et al. -Characterization of pyruvate kinase from the anoxia tolerant turtle, Trachemys scripta elegans: a potential role for enzyme methylation during metabolic rate depression. PeerJ. 2018,6:e4918. doi: 10.7717/peerj.4918
    Read this paper
  • Chang SJ, Liao EC, Yeo HY, et al. Proteomic investigating the cooperative lethal effect of EGFR and MDM2 inhibitors on ovarian carcinoma. Arch Biochem Biophys. 2018,647:10-32. doi: 10.1016/j.abb.2018.04.004
    Read this paper
  • May EW, Lin ST, Lin CC, et al. Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance. Pharmacol Res. 2014,90:1-17. doi: 10.1016/j.phrs.2014.08.007
    Read this paper