PKSI-527 [128837-71-8]

TargetMol Chemicals

PKSI-527 [128837-71-8]

14

128837-71-8

Chemical

Research Use Only

PKSI-527

C25H32ClN3O4

473.99

PKSI-527 is an inhibitor of plasma kallikrein (Ki = 0.81 microM). It is selective for plasma kallikrein over glandular kallikrein, plasmin, thrombin, urokinase, and Factor Xa (Kis = >500, 390, >500, 200, and >500 microM, respectively). PKSI-527 reduces bradykinin generation induced by kaolin and lambda-carrageenan ex vivo in human plasma. It also prolongs partial thromboplastin and euglobulin clot lysis times.

3 years

[C@@H](CC1=CC=CC=C1)(NC(=O)[C@H]2CC[C@H](CN)CC2)C(NC3=CC=C(CC(O)=O)C=C3)=O.Cl

-20°C

12352200