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PLA2G4A antibody

Research Use Only
GTX110218
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPLA2G4A
Price on request
Packing Size
Large volume orders?
Order with a bulk request

Overview

  • Supplier
    GeneTex
  • Product Name
    PLA2G4A antibody
  • Delivery Days Customer
    9
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.3 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5321
  • Target name
    PLA2G4A
  • Target description
    phospholipase A2 group IVA
  • Target synonyms
    calcium-dependent phospholipid-binding protein; cPLA2; cPLA2-alpha; cytosolic phospholipase A2; GURDP; lysophospholipase; phosphatidylcholine 2-acylhydrolase; phospholipase A2, group IVA (cytosolic, calcium-dependent); PLA2G4
  • Host
    Rabbit
  • Isotype
    IgG
  • Scientific Description
    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    2°C to 8°C,-20°C or -80°C
  • UNSPSC
    12352203

References

  • Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling. Ueno H et al., 2020 Jul, Am J Respir Cell Mol Biol
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  • Cytosolic phospholipase A2alpha modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma. Guo P et al., 2019 May, Cancer Biol Med
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  • cPLA2alpha mediates TGF-beta-induced epithelial-mesenchymal transition in breast cancer through PI3k/Akt signaling. Chen L et al., 2017 Apr 6, Cell Death Dis
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