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PLA2G4A antibody

GTX110218
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPLA2G4A
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Overview

  • Supplier
    GeneTex
  • Product Name
    PLA2G4A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.3 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5321
  • Target name
    PLA2G4A
  • Target description
    phospholipase A2 group IVA
  • Target synonyms
    GURDP, PLA2G4, cPLA2, cPLA2-alpha, cytosolic phospholipase A2, calcium-dependent phospholipid-binding protein, lysophospholipase, phosphatidylcholine 2-acylhydrolase, phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP47712
  • Protein Name
    Cytosolic phospholipase A2
  • Scientific Description
    This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Xu S, Tuo QZ, Meng J, et al. Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway. Transl Oncol. 2024,39:101817. doi: 10.1016/j.tranon.2023.101817
    Read this paper
  • Ueno H, Koya T, Takeuchi H, et al. Cysteinyl Leukotriene Synthesis via Phospholipase A2 Group IV Mediates Exercise-induced Bronchoconstriction and Airway Remodeling. Am J Respir Cell Mol Biol. 2020,63(1):57-66. doi: 10.1165/rcmb.2019-0325OC
    Read this paper
  • Guo P, He Y, Chen L, et al. Cytosolic phospholipase A2α modulates cell-matrix adhesion via the FAK/paxillin pathway in hepatocellular carcinoma. Cancer Biol Med. 2019,16(2):377-390. doi: 10.20892/j.issn.2095-3941.2018.0386
    Read this paper
  • Chen L, Fu H, Luo Y, et al. cPLA2α mediates TGF-β-induced epithelial-mesenchymal transition in breast cancer through PI3k/Akt signaling. Cell Death Dis. 2017,8(4):e2728. doi: 10.1038/cddis.2017.152
    Read this paper

Datasheet

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