WB analysis of purified human prekallikrein protein (Lane 1) and normal human plasma (Lanes 2 and 3) lysates using GTX21006 Plasma Kallikrein 1B antibody [13G11].
WB analysis of purified human prekallikrein protein (Lane 1) and normal human plasma (Lanes 2 and 3) lysates using GTX21006 Plasma Kallikrein 1B antibody [13G11].
Plasma Kallikrein 1B antibody [13G11]
GTX21006
Overview
- SupplierGeneTex
- Product NamePlasma Kallikrein 1B antibody [13G11]
- Delivery Days Customer9
- Antibody SpecificityThis antibody recognizes two variants of prekallikrein in human plasma, 88kDa and 85kDa, and its activation products kallikrein, the complexes formed by kallikrein with its endogenous inhibitors C1 inhibitor, alpha-2-macroglobulin and antithrombin III, an
- Application Supplier NoteWB: 1-5microg/ml. ELISA: 5-10microg/ml. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsWestern Blot, ELISA
- CertificationResearch Use Only
- ClonalityMonoclonal
- Clone ID13G11
- ConjugateUnconjugated
- Gene ID3818
- Target nameKLKB1
- Target descriptionkallikrein B1
- Target synonymskallikrein B, plasma (Fletcher factor) 1; kininogenin; KLK3; PKK; PKKD; plasma kallikrein; plasma prekallikrein; PPK
- HostMouse
- IsotypeIgG1
- Protein IDP03952
- Protein NamePlasma kallikrein
- Scientific DescriptionThis gene encodes a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. The encoded preproprotein present in plasma as a non-covalent complex with high molecular weight kininogen undergoes proteolytic processing mediated by activated coagulation factor XII to generate a disulfide-linked, heterodimeric serine protease comprised of heavy and light chains. Certain mutations in this gene cause prekallikrein deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
- ReactivityHuman
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Prekallikrein inhibits innate immune signaling in the lung and impairs host defense during pneumosepsis in mice. Ding C et al., 2020 Jan, J PatholRead more