PLEKHO1 Antibody

Cusabio

PLEKHO1 Antibody

20

ELISA, ImmunoHistoChemistry

Research Use Only

Polyclonal

Unconjugated

PLEKHO1

pleckstrin homology domain containing O1

CKIP-1, CKIP1, JBP, OC120, pleckstrin homology domain-containing family O member 1, C-Jun-binding protein, CK2 interacting protein 1; HQ0024c protein, CK2-interacting protein 1, PH domain-containing family O member 1, casein kinase 2-interacting protein 1, osteoclast maturation-associated gene 120 protein

Rabbit

IgG

Pleckstrin homology domain-containing family O member 1

Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1 and SMURF1.It plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). Appears to target ATM to the plasma membrane,and also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. The protein implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Human, Mouse, Rat

-20°C or -80°C

41116161