PLX-4720

MedChem Express

PLX-4720 [918505-84-7]

10

918505-84-7

Research Use Only

99.91

C17H14ClF2N3O3S

413.83

PLX-4720 is a potent and selective inhibitor of? B-Raf V600E ?with? IC 50 ?of 13 nM in a cell-free assay, equally potent to c-Raf-1(Y340D and Y341D mutations), and 10-fold selectivity for B-Raf V600E than wild-type B-Raf.

O=S(NC1=CC=C(C(C(C2=CNC3=NC=C(C=C23)Cl)=O)=C1F)F)(CCC)=O

-20°C,2°C to 8°C

12352200