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PNMT-IN-1

HY-149389
MedChem Express
Molecular Weight623.53
Product group Chemicals
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PNMT-IN-1
  • Delivery Days Customer
    14
  • Certification
    Research Use Only
  • Molecular Formula
    C27H36Cl2N8O5
  • Molecular Weight
    623.53
  • Scientific Description
    PNMT-IN-1 (inhibtor 4) is a specific inhibitor of phenylethanolamine N-methyltransferas (PNMT) with a Ki value of 1.2 nM and a IC50 value of 81 nM. PNMT-IN-1 also inhibits the vitality of DNMT1 and DNMT3b, with the IC50 value of 61 microM and 17 microM, respectively, and has an antagonistic effect on epinephrine.PNMT-IN-1 (inhibtor 4 ) is a second generation inhibitor[1].
  • SMILES
    ClC1=C(Cl)C=CC2=C1CNCC2CCCCN(C[C@@H]3[C@@H](O)[C@@H](O)[C@H](N4C=NC5=C4N=CN=C5N)O3)CC[C@H](N)C(O)=O
  • UNSPSC
    12131703