PNR-7-02 [1633660-76-0]

MedChem Express

PNR-7-02 [1633660-76-0]

9

1633660-76-0

Research Use Only

98.0

C24H16ClN3O2S

445.92

PNR-7-02 inhibits Pol eta function with an IC50 value of near 8 microM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (lambda). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].

O=C1NC(NC(/C1=C\C2=CN(CC3=CC4=C(C=CC=C4)C=C3)C5=C2C=C(Cl)C=C5)=O)=S

-20°C,2°C to 8°C

12352200