PNRC2 Polyclonal Antibody
RD218895A
ApplicationsELISA, ImmunoHistoChemistry
Product group Antibodies
ReactivityHuman, Mouse, Rat
TargetPNRC2
Overview
- SupplierReddot Biotech
- Product NamePNRC2 Polyclonal Antibody
- Delivery Days Customer5
- ApplicationsELISA, ImmunoHistoChemistry
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.54 mg/ml
- ConjugateUnconjugated
- Gene ID55629
- Target namePNRC2
- Target descriptionproline rich nuclear receptor coactivator 2
- Target synonymsproline-rich nuclear receptor coactivator 2
- HostRabbit
- IsotypeIgG
- Scientific DescriptionInvolved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery (PubMed:19150429). May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs (PubMed:19150429). Required for UPF1/RENT1 localization to the P-body (PubMed:19150429). Plays a role in glucocorticoid receptor-mediated mRNA degradation by interacting with the glucocorticoid receptor NR3C1 in a ligand-dependent manner when it is bound to the 5 UTR of target mRNAs and recruiting the RNA helicase UPF1 and the mRNA-decapping enzyme DCP1A, leading to RNA decay (PubMed:25775514). Also acts as a nuclear receptor coactivator (PubMed:11574675). May play a role in controlling the energy balance between energy storage and energy expenditure (By similarity).
- ReactivityHuman, Mouse, Rat
- Storage Instruction-20°C
- UNSPSC12352203