PNU-107484A [200266-76-8]
HY-117106
CAS Number200266-76-8
Product group Chemicals
Molecular Weight358.87
Overview
- SupplierMedChem Express
- Product NamePNU-107484A [200266-76-8]
- Delivery Days Customer9
- CAS Number200266-76-8
- CertificationResearch Use Only
- Molecular FormulaC18H23ClN6
- Molecular Weight358.87
- Scientific DescriptionPNU-107484A is a GABAA receptor ligand that exhibits target activity mechanisms dependent on alpha isoforms. In the alpha1beta2gamma2 subtype, PNU-107484A acts as a positive allosteric modulator, enhancing GABA-induced Cl- currents, while it inhibits the currents in the alpha3beta2gamma2 and alpha6beta2gamma2 subtypes. The half-maximal concentrations for the alpha1beta2gamma2, alpha3beta2gamma2, and alpha6beta2gamma2 subtypes are 3.1, 4.2, and 3.5 microM, respectively. PNU-107484A can be used as a probe to investigate the physiological roles of different alpha isoform subtypes[1].
- SMILESCN1C2=NC(N3CCCC3)=NC(N4CCCC4)=C2C5=C1C=CN=C5.Cl
- UNSPSC12352200