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POM121 antibody [N2N3]

GTX102128
GeneTex
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPOM121
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Overview

  • Supplier
    GeneTex
  • Product Name
    POM121 antibody [N2N3]
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.16 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID9883
  • Target name
    POM121
  • Target description
    POM121 transmembrane nucleoporin
  • Target synonyms
    P145, POM121A, nuclear envelope pore membrane protein POM 121, POM121 membrane glycoprotein, nuclear envelope pore membrane protein POM 121A, nuclear pore membrane protein 121 kDa, nucleoporin Nup121
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDQ96HA1
  • Protein Name
    Nuclear envelope pore membrane protein POM 121
  • Scientific Description
    The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq]
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Xue G, Yu HJ, Buffone C, et al. The HIV-1 capsid core is an opportunistic nuclear import receptor. Nat Commun. 2023,14(1):3782. doi: 10.1038/s41467-023-39146-5
    Read this paper
  • Andronov L, Genthial R, Hentsch D, et al. splitSMLM, a spectral demixing method for high-precision multi-color localization microscopy applied to nuclear pore complexes. Commun Biol. 2022,5(1):1100. doi: 10.1038/s42003-022-04040-1
    Read this paper
  • LaJoie D, Turkmen AM, Mackay DR, et al. A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents. Mol Biol Cell. 2022,33(13):ar117. doi: 10.1091/mbc.E22-05-0189
    Read this paper
  • Marco S, Neilson M, Moore M, et al. Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nat Commun. 2021,12(1):6829. doi: 10.1038/s41467-021-26839-y
    Read this paper
  • Agote-Aran A, Schmucker S, Jerabkova K, et al. Spatial control of nucleoporin condensation by fragile X-related proteins. EMBO J. 2020,39(20):e104467. doi: 10.15252/embj.2020104467
    Read this paper
  • Hoffman LM, Smith MA, Jensen CC, et al. Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes. Mol Biol Cell. 2020,31(16):1774-1787. doi: 10.1091/mbc.E19-01-0027
    Read this paper
  • Ma H, Li L, Jia L, et al. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. J Cancer. 2019,10(19):4473-4480. doi: 10.7150/jca.33368
    Read this paper
  • McCloskey A, Ibarra A, Hetzer MW. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes Dev. 2018,32(19-20):1321-1331. doi: 10.1101/gad.315523.118
    Read this paper
  • Rodriguez-Bravo V, Pippa R, Song WM, et al. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell. 2018,174(5):1200-1215.e20. doi: 10.1016/j.cell.2018.07.015
    Read this paper
  • Franks TM, Benner C, Narvaiza I, et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016,30(10):1155-71. doi: 10.1101/gad.280941.116
    Read this paper