POM121 antibody [N2N3]
GTX102128
ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
TargetPOM121
Overview
- SupplierGeneTex
- Product NamePOM121 antibody [N2N3]
- Delivery Days Customer9
- Application Supplier NoteWB: 1:500-1:3000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
- ApplicationsImmunoFluorescence, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
- CertificationResearch Use Only
- ClonalityPolyclonal
- Concentration0.16 mg/ml
- ConjugateUnconjugated
- Gene ID9883
- Target namePOM121
- Target descriptionPOM121 transmembrane nucleoporin
- Target synonymsP145, POM121A, nuclear envelope pore membrane protein POM 121, POM121 membrane glycoprotein, nuclear envelope pore membrane protein POM 121A, nuclear pore membrane protein 121 kDa, nucleoporin Nup121
- HostRabbit
- IsotypeIgG
- Protein IDQ96HA1
- Protein NameNuclear envelope pore membrane protein POM 121
- Scientific DescriptionThe nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. [provided by RefSeq]
- Storage Instruction-20°C or -80°C,2°C to 8°C
- UNSPSC12352203
References
- Xue G, Yu HJ, Buffone C, et al. The HIV-1 capsid core is an opportunistic nuclear import receptor. Nat Commun. 2023,14(1):3782. doi: 10.1038/s41467-023-39146-5Read this paper
- Andronov L, Genthial R, Hentsch D, et al. splitSMLM, a spectral demixing method for high-precision multi-color localization microscopy applied to nuclear pore complexes. Commun Biol. 2022,5(1):1100. doi: 10.1038/s42003-022-04040-1Read this paper
- LaJoie D, Turkmen AM, Mackay DR, et al. A role for Nup153 in nuclear assembly reveals differential requirements for targeting of nuclear envelope constituents. Mol Biol Cell. 2022,33(13):ar117. doi: 10.1091/mbc.E22-05-0189Read this paper
- Marco S, Neilson M, Moore M, et al. Nuclear-capture of endosomes depletes nuclear G-actin to promote SRF/MRTF activation and cancer cell invasion. Nat Commun. 2021,12(1):6829. doi: 10.1038/s41467-021-26839-yRead this paper
- Agote-Aran A, Schmucker S, Jerabkova K, et al. Spatial control of nucleoporin condensation by fragile X-related proteins. EMBO J. 2020,39(20):e104467. doi: 10.15252/embj.2020104467Read this paper
- Hoffman LM, Smith MA, Jensen CC, et al. Mechanical stress triggers nuclear remodeling and the formation of transmembrane actin nuclear lines with associated nuclear pore complexes. Mol Biol Cell. 2020,31(16):1774-1787. doi: 10.1091/mbc.E19-01-0027Read this paper
- Ma H, Li L, Jia L, et al. POM121 is identified as a novel prognostic marker of oral squamous cell carcinoma. J Cancer. 2019,10(19):4473-4480. doi: 10.7150/jca.33368Read this paper
- McCloskey A, Ibarra A, Hetzer MW. Tpr regulates the total number of nuclear pore complexes per cell nucleus. Genes Dev. 2018,32(19-20):1321-1331. doi: 10.1101/gad.315523.118Read this paper
- Rodriguez-Bravo V, Pippa R, Song WM, et al. Nuclear Pores Promote Lethal Prostate Cancer by Increasing POM121-Driven E2F1, MYC, and AR Nuclear Import. Cell. 2018,174(5):1200-1215.e20. doi: 10.1016/j.cell.2018.07.015Read this paper
- Franks TM, Benner C, Narvaiza I, et al. Evolution of a transcriptional regulator from a transmembrane nucleoporin. Genes Dev. 2016,30(10):1155-71. doi: 10.1101/gad.280941.116Read this paper



