Pomalidomide 4-PEG3-azide [2271036-46-3]

MedChem Express

Pomalidomide 4-PEG3-azide [2271036-46-3]

10

2271036-46-3

Research Use Only

96.06

C21H26N6O7

474.47

Pomalidomide 4-PEG3-azide is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide-based cereblon ligand and a linker. Pomalidomide 4-PEG3-azide can be used for the synthesis of iRucaparib-TP3 (Compound 3). iRucaparib-TP3 is a highly efficient PARP1 degrader based on Rucaparib by using the PROTAC approach[1]. Pomalidomide 4-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCN=[N+]=[N-])=O

-20°C,2°C to 8°C

41115800