Pomalidomide-PEG1-C2-N3 [2271036-44-1]

MedChem Express

Pomalidomide-PEG1-C2-N3 [2271036-44-1]

10

2271036-44-1

Research Use Only

99.91

C17H18N6O5

386.36

Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1]. Pomalidomide-PEG1-C2-N3 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN=[N+]=[N-])=O

-20°C

41115800