Ponalrestat [72702-95-5]

MedChem Express

Ponalrestat [72702-95-5]

9

72702-95-5

Research Use Only

99.51

C17H12BrFN2O3

391.19

Ponalrestat (ICI 128436) is an orally active, selective and noncompetitive aldose reductase (AKR1B1; ALR) inhibitor. Ponalrestat selectively inhibits ALR2 (Ki=7.7 nM) over ALR1 (Ki=60 microM). Ponalrestat inhibits the conversion of glucose to sorbitol[1][2][3].

OC(CC(C1=C2C=CC=C1)=NN(CC3=C(C=C(Br)C=C3)F)C2=O)=O

2°C to 8°C

12352200