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ProductsBack/Ponasterone A [13408-56-5]
Chemical Structure
Chemical Structure
Chemical Structure

Ponasterone A [13408-56-5]

Research Use Only
AG-CN2-0053
AdipoGen Life Sciences
CAS Number13408-56-5
DownloadMSDS
Product group Chemicals
Estimated Purity>95%
Molecular Weight464.6
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Overview

  • Supplier
    AdipoGen Life Sciences
  • Product Name
    Ponasterone A
  • Delivery Days Customer
    10
  • CAS Number
    13408-56-5
  • Certification
    Research Use Only
  • Estimated Purity
    >95%
  • Molecular Formula
    C27H44O6
  • Molecular Weight
    464.6
  • Scientific Description
    A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to muristerone A. Functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Induces expression of beta-galactosidase to levels similar to those obtained with muristerone A induction. Potent compound for ecdysteroid activity. Insect steroid hormone involved in regulating metamorphosis. - Chemical. CAS: 13408-56-5. Formula: C27H44O6. MW: 464.6. Semi-synthetic. A member of the ecdysteroid family. Ecdysone receptor (EcR) agonist. Analog of ecdysone with similar properties to muristerone A. Functional, reliable and economical substitute for muristerone A as an inducer for the ecdysone-inducible mammalian expression system. Induces expression of beta-galactosidase to levels similar to those obtained with muristerone A induction. Potent compound for ecdysteroid activity. Insect steroid hormone involved in regulating metamorphosis.
  • SMILES
    [H][C@@]1(CC[C@@]2(O)C3=CC(=O)[C@]4([H])C[C@@H](O)[C@@H](O)C[C@]4(C)[C@@]3([H])CC[C@]12C)[C@@](C)(O)[C@H](O)CCC(C)C
  • Storage Instruction
    -20°C,2°C to 8°C
  • UNSPSC
    12352200

References

  • Extraction of ponasterone A and ecdysterone from podocarpaceae and related plants: S. Imai et al.; Steroids 10, 557 (1967)
  • Ecdysones and analogs: effects on development and reproduction of insects: W.E. Robbins, et al.; Science 161, 1158 (1968)
  • The uptake and release of ponasterone A by the Kc cell line of Drosophila melanogaster: C. Beckers, et al.; Mol. Cell. Endocrinol. 17, 51 (1980)
  • Past and present studies with ponasterones, the first insect molting hormones from plants: K. Nakanishi; Steroids 57, 649 (1992)
  • Identification of ligands and coligands for the ecdysone-regulated gene switch: E. Saez, et al.; PNAS 97, 14512 (2000)
  • Mammalian 5'(3')-deoxyribonucleotidase, cDNA cloning, and overexpression of the enzyme in Escherichia coli and mammalian cells: C. Rampazzo, et al.; J. Biol. Chem. 275, 5409 (2000)
  • Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice: C. Albanese, et al.; FASEB J. 14, 877 (2000)
  • The ecdysone inducible gene expression system: unexpected effects of muristerone A and ponasterone A on cytokine signaling in mammalian cells: S. Constantino, et al.; Eur. Cytokine Netw. 12, 365 (2001)
  • Recent advances in inducible expression in transgenic mice: C. Albanese, et al.; Semin. Cell. Dev. Biol. 13, 129 (2002)
  • Potent and selective partial ecdysone agonist activity of chromafenozide in Sf9 cells: T. Toya, et al.; BBRC 292, 1087 (2002)