Ponesimod

MedChem Express

Ponesimod [854107-55-4]

10

854107-55-4

99.81

C23H25ClN2O4S

460.97

Ponesimod (ACT-128800) is a potent, selective and orally active agonist of S1P 1 , with an IC 50 of 6 nM in a radioligand binding assay. Ponesimod activates S1P 1 -mediated signal transduction with high potency ( EC 50 =5.7 nM). Ponesimod can protect against lymphocyte-mediated tissue inflammation [1] [2] [3] .

O=C1N(C2=CC=CC=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC

-20°C,2°C to 8°C

12352200