Ponesimod-d4

MedChem Express

Ponesimod-d4

14

Research Use Only

C23H21D4ClN2O4S

465.00

Ponesimod-d 4 (ACT-128800-d 4 ) is the deuterium labeled Ponesimod (HY-10569) [1] . Ponesimod (ACT-128800) is a potent, selective and orally active agonist of S1P 1 , with an IC 50 of 6 nM in a radioligand binding assay. Ponesimod activates S1P 1 -mediated signal transduction with high potency ( EC 50 =5.7 nM). Ponesimod can protect against lymphocyte-mediated tissue inflammation [2] [3] [4] .

O=C1N(C2=C([2H])C([2H])=C([2H])C([2H])=C2C)/C(S/C1=C\C3=CC=C(OC[C@H](O)CO)C(Cl)=C3)=N/CCC

12352200