PP242 [1092351-67-1]
27063
CAS Number1092351-67-1
Product group Chemicals
Estimated Purity≥99%
Molecular Weight308.3 Da
Overview
- SupplierBPS Bioscience
- Product NamePP242
- Delivery Days Customer7
- CAS Number1092351-67-1
- CertificationResearch Use Only
- Estimated Purity≥99%
- Molecular FormulaC16H16N6O
- Molecular Weight308.3 Da
- Scientific DescriptionPP242 is an inhibitor at the kinase domain of the mammalian target of rapamycin (mTOR), which is a Ser/Thr kinase and a cell growth controller. PP242 inhibits mTORC1 more effectively than rapamycin. Unlike rapamycin, PP242 inhibits both mTORC1 and mTORC2 with IC50 values of 0.03 and 0.058 microM, respectively and it can inhibit cap-dependent translation. PP242 functions by blocking the phosphorylation of Akt at S473 and preventing mTOR activation. PP242 exhitibits IC50 values for other kinases of 0.11 microM (JAK2), 0.41 microM (DNAPK), 0.05 microM (PKC?), 0.2 microM (PKCbeta I and II), 4.4 microM (EGFR), and1.5 microM (VEGFR2).
- Storage Instruction-20°C
- UNSPSC51202000