PPP1R8 Antibody

Cusabio

PPP1R8 Antibody

20

Western Blot, ELISA

Research Use Only

Polyclonal

Unconjugated

PPP1R8

protein phosphatase 1 regulatory subunit 8

activator of RNA decay; ARD1; ARD-1; NIPP1; NIPP-1; nuclear inhibitor of protein phosphatase 1; nuclear inhibitor of protein phosphatase-1 alpha; nuclear inhibitor of protein phosphatase-1 beta; nuclear subunit of PP-1; PRO2047; protein phosphatase 1, regulatory (inhibitor) subunit 8; RNase E

Rabbit

IgG

Nuclear inhibitor of protein phosphatase 1

Inhibitor subunit of the major nuclear protein phosphatase-1 (PP-1). It has RNA-binding activity but does not cleave RNA and may target PP-1 to RNA-associated substrates. May also be involved in pre-mRNA splicing. Binds DNA and might act as a transcriptional repressor. Seems to be required for cell proliferation. Isoform Gamma is a site-specific single-strand endoribonuclease that cleaves single strand RNA 3 to purines and pyrimidines in A+U-rich regions. It generates 5-phosphate termini at the site of cleavage. This isoform doesnot inhibit PP-1. May be implicated in mRNA splicing. Wang M., Proc. Natl. Acad. Sci. U.S.A. 91:10591-10595(1994). Van Eynde A., Eur. J. Biochem. 261:291-300(1999). Liu J.P., Submitted (FEB-1999) to the EMBL/GenBank/DDBJ databases.

Human, Mouse

-20°C or -80°C

12352203