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PPP2R1A antibody

GTX102206
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPPP2R1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    PPP2R1A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:2500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.12 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5518
  • Target name
    PPP2R1A
  • Target description
    protein phosphatase 2 scaffold subunit Aalpha
  • Target synonyms
    HJS2, MRD36, PP2A-Aalpha, PP2AA, PP2AAALPHA, PR65A, serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, medium tumor antigen-associated 61 KDA protein, protein phosphatase 2, regulatory subunit A, alpha, testicular secretory protein Li 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP30153
  • Protein Name
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  • Scientific Description
    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Yen YT, Chien M, Wu PY, et al. Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response. Nat Commun. 2021,12(1):7297. doi: 10.1038/s41467-021-27620-x
    Read this paper
  • Yen YT, Chien M, Wu PY, et al. PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Commun Biol. 2021,4(1):658. doi: 10.1038/s42003-021-02175-1
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  • Yen YT, Chien M, Lai YC, et al. PP2A Deficiency Enhances Carcinogenesis of Lgr5(+) Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 2019,9(1). doi: 10.3390/cells9010090
    Read this paper
  • Adhikari B, De Silva B, Molina JA, et al. Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. Biochim Biophys Acta Mol Basis Dis. 2019,1865(2):322-328. doi: 10.1016/j.bbadis.2018.11.011
    Read this paper
  • Martina JA, Puertollano R. Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress. J Biol Chem. 2018,293(32):12525-12534. doi: 10.1074/jbc.RA118.003471
    Read this paper
  • Tsao HW, Tai TS, Tseng W, et al. Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter. Proc Natl Acad Sci U S A. 2013,110(39):15776-81. doi: 10.1073/pnas.1304343110
    Read this paper