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PPP2R1A antibody

GTX102206
GeneTex
ApplicationsImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
Product group Antibodies
ReactivityHuman, Mouse
TargetPPP2R1A
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Overview

  • Supplier
    GeneTex
  • Product Name
    PPP2R1A antibody
  • Delivery Days Customer
    9
  • Application Supplier Note
    WB: 1:500-1:10000. ICC/IF: 1:100-1:1000. IHC-P: 1:100-1:2500. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
  • Applications
    ImmunoFluorescence, ImmunoPrecipitation, Western Blot, ImmunoCytoChemistry, ImmunoHistoChemistry, ImmunoHistoChemistry Paraffin
  • Certification
    Research Use Only
  • Clonality
    Polyclonal
  • Concentration
    0.12 mg/ml
  • Conjugate
    Unconjugated
  • Gene ID5518
  • Target name
    PPP2R1A
  • Target description
    protein phosphatase 2 scaffold subunit Aalpha
  • Target synonyms
    medium tumor antigen-associated 61 KDA protein; MRD36; PP2AA; PP2AAALPHA; PP2A-Aalpha; PR65A; protein phosphatase 2, regulatory subunit A, alpha; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; testicular secretory protein Li 1
  • Host
    Rabbit
  • Isotype
    IgG
  • Protein IDP30153
  • Protein Name
    Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
  • Scientific Description
    This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. [provided by RefSeq]
  • Reactivity
    Human, Mouse
  • Storage Instruction
    -20°C or -80°C,2°C to 8°C
  • UNSPSC
    12352203

References

  • Protein phosphatase 2A inactivation induces microsatellite instability, neoantigen production and immune response. Yen YT et al., 2021 Dec 15, Nat Commun
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  • PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylation. Yen YT et al., 2021 Jun 2, Commun Biol
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  • PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo. Yen YT et al., 2019 Dec 30, Cells
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  • Neuronal ceroid lipofuscinosis related ER membrane protein CLN8 regulates PP2A activity and ceramide levels. Adhikari B et al., 2019 Feb 1, Biochim Biophys Acta Mol Basis Dis
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  • Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress. Martina JA et al., 2018 Aug 10, J Biol Chem
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  • Ets-1 facilitates nuclear entry of NFAT proteins and their recruitment to the IL-2 promoter. Tsao HW et al., 2013 Sep 24, Proc Natl Acad Sci U S A
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  • The Royal Australasian College of Physicians Golden Jubilee meeting. Sydney, 8-13 May 1988. Proceedings of meetings of special societies and colleges. Abstracts., 1988 May, Aust N Z J Med
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