PPY-A [875634-01-8]

MedChem Express

PPY-A [875634-01-8]

10

875634-01-8

Research Use Only

C22H20N4O2

372.42

PPY-A is a potent T315I mutant and wild-type Abl kinases inhibitor with IC50s of 9 and 20 nM, respectively. PPY-A inhibits Ba F3 cells transformed with wild-type Abl and Abl T315I mutantl with IC50s of 390 and 180 nM, respectively. PPY-A can be used for the research of chronic myeloid leukemia (CML)[1].

O=C(C1=CC(C2=CN=C(NC=C3C4=CC=CC=C4OC)C3=C2)=CN=C1)N(C)C

12352200