Pralatrexate, (R)- [1320211-70-8]

TargetMol Chemicals

Pralatrexate, (R)- [1320211-70-8]

114

1320211-70-8

Research Use Only

Pralatrexate, (R)-

C23H23N7O5

477.47

Pralatrexate, (R)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.

3 years

NC=1C2=C(N=CC(C[C@@H](CC#C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1

-20°C

12352200