Presenilin 1 blocking peptide

GeneTex

Presenilin 1 blocking peptide

9

Neutralisation/Blocking

Research Use Only

200 ug/ml

Unconjugated

PSEN1

presenilin 1

ACNINV3, AD3, CMD1U, FAD, PS-1, PS1, PSNL1, S182, presenilin-1, familial Alzheimer Disease

Alzheimers disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]

-20°C

41116100

Human