Prexasertib

MedChem Express

Prexasertib [1234015-52-1]

10

1234015-52-1

Research Use Only

98.74

C18H19N7O2

365.39

Prexasertib (LY2606368) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K i of 0.9 nM and an IC 50 of 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis . Prexasertib shows potent anti-tumor activity [1] [2] .

NCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2

-20°C,2°C to 8°C

12352200