Prexasertib (dihydrochloride) [1234015-54-3]
![Research Use Only](static/images/certificates/ruo.jpg)
HY-18174A
CAS Number1234015-54-3
Product group Chemicals
Estimated Purity99.41
Molecular Weight438.31
Overview
- SupplierMedChem Express
- Product NamePrexasertib (dihydrochloride) [1234015-54-3]
- Delivery Days Customer10
- CAS Number1234015-54-3
- CertificationResearch Use Only
- Estimated Purity99.41
- Molecular FormulaC18H21Cl2N7O2
- Molecular Weight438.31
- Scientific DescriptionPrexasertib dihydrochloride (LY2606368 dihydrochloride) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a Ki of 0.9 nM and an IC50 of 50=8 nM) and RSK1 (IC50=9 nM). Prexasertib dihydrochloride causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis. Prexasertib dihydrochloride shows potent anti-tumor activity[1][2].
- SMILESNCCCOC(C=CC=C1OC)=C1C2=CC(NC3=NC=C(C#N)N=C3)=NN2.[H]Cl.[H]Cl
- Storage Instruction2°C to 8°C
- UNSPSC12352200