Prexasertib dimesylate [1234015-58-7]
T38620
Overview
- SupplierTargetMol Chemicals
- Product NamePrexasertib dimesylate [1234015-58-7]
- Delivery Days Customer14
- CAS Number1234015-58-7
- Category SupplierChemical
- CertificationResearch Use Only
- Chemical NamePrexasertib dimesylate
- Molecular FormulaC20H27N7O8S2
- Molecular Weight557.6
- Scientific DescriptionPrexasertib dimesylate (LY2606368 dimesylate) is a highly selective, ATP-competitive, second-generation inhibitor of checkpoint kinase 1 (CHK1), with a K_i of 0.9 nM and an IC_50 of <1 nM, and also effectively inhibits CHK2 (IC_50 = 8 nM) and RSK1 (IC_50 = 9 nM). Its mechanism induces double-stranded DNA breakage and replication catastrophe, leading to apoptosis, and demonstrates potent anti-tumor activity.
- Shelf life instruction3 years
- SMILESCS(O)(=O)=O.CS(O)(=O)=O.COc1cccc(OCCCN)c1-c1cc(Nc2cnc(cn2)C#N)n[nH]1
- Storage Instruction-20°C
- UNSPSC12352200
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Product group Chemicals
Prexasertib (dimesylate)HY-18174E
CAS Number1234015-58-7
Estimated Purity99.04
Molecular Weight557.60
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Product group Chemicals
Prexasertib dimesylateORB1691881
CAS Number1234015-58-7
Estimated Purity98%
Molecular Weight557.6
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