Prexasertib (Mesylate Hydrate)

MedChem Express

Prexasertib (Mesylate Hydrate) [1234015-57-6]

10

1234015-57-6

Research Use Only

C19H25N7O6S

479.51

Prexasertib Mesylate Hydrate (LY2606368 Mesylate Hydrate) is a selective, ATP-competitive second-generation checkpoint kinase 1 (CHK1) inhibitor with a K i of 0.9 nM and an IC 50 of 50 =8 nM) and RSK1 (IC 50 =9 nM). Prexasertib Mesylate Hydrate causes double-stranded DNA breakage and replication catastrophe resulting in apoptosis . Prexasertib Mesylate Hydrate shows potent anti-tumor activity [1] [2] .

N#CC1=NC=C(NC2=NNC(C3=C(OC)C=CC=C3OCCCN)=C2)N=C1.CS(=O)(O)=O.O

12352200