PRG2 antibody [BMK-13]

GeneTex

PRG2 antibody [BMK-13]

9

Clone BMK-13 recongises the Eosinophil Major Basic Protein (EMBP, PRG2) and cross reacts weakly with basophils which also contain low levels of EMBP. No cross reactivity with other human cells or proteins has been noted.

IHC-P: 1/20-1/50. IHC-Fr: 1/20-1/50. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.

ImmunoHistoChemistry, ImmunoHistoChemistry Frozen, ImmunoHistoChemistry Paraffin

Research Use Only

Monoclonal

BMK-13

0.1 mg/ml

Unconjugated

PRG2

proteoglycan 2, pro eosinophil major basic protein

BMPG; bone marrow proteoglycan; eosinophil granule major basic protein; eosinophil major basic protein; MBP; MBP1; natural killer cell activator; proMBP; proteoglycan 2 preproprotein; proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)

Mouse

IgG1

Bone marrow proteoglycan

The protein encoded by this gene is the predominant constituent of the crystalline core of the eosinophil granule. High levels of the proform of this protein are also present in placenta and pregnancy serum, where it exists as a complex with several other proteins including pregnancy-associated plasma protein A (PAPPA), angiotensinogen (AGT), and C3dg. This protein may be involved in antiparasitic defense mechanisms as a cytotoxin and helminthotoxin, and in immune hypersensitivity reactions. The encoded protein contains a peptide that displays potent antimicrobial activity against Gram-positive bacteria, Gram-negative bacteria, and fungi. It is directly implicated in epithelial cell damage, exfoliation, and bronchospasm in allergic diseases. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2014]

Human, Rat

-20°C or -80°C,2°C to 8°C

12352203