PRGL493 [2479378-45-3]

TargetMol Chemicals

PRGL493 [2479378-45-3]

10

2479378-45-3

Chemical

Research Use Only

PRGL493

99.11%

C25H21N7O2

451.48

PRGL493 is an inhibitor of long-chain acyl-CoA synthetase 4 (ACSL4).1It inhibits formation of arachidonoyl-CoA (AA-CoA) from arachidonic acid in, as well as the proliferation and migration of, PC3 and MDA-MB-231 cancer cells when used at a concentration of 50 microM. PRGL493 (5 microM) reduces production of progesterone induced by 8-Br-cyclic AMP (8-Br-cAMP) in MA-10 Leydig tumor cells. It inhibits tumor growth in a PC3 mouse xenograft model when administered at a dose of 0.25 mg/kg.

3 years

CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1

-20°C

12352200