Prnp Antibody

Cusabio

Prnp Antibody

20

ELISA

Research Use Only

Polyclonal

Unconjugated

Prnp

prion protein

PrP, Prn, major prion protein, prion protein, PrP, prion protein, structural

Rabbit

IgG

Major prion protein

Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.

Rat

-20°C or -80°C

41116161