PRO-6E [2353493-69-1]

MedChem Express

PRO-6E [2353493-69-1]

5

2353493-69-1

Research Use Only

99.85

C42H44Cl2FN7O7

848.75

PRO-6E is an oral active PROTAC based on Cereblon ligand, and induces the degradation of MET with maximum degradation of 81.9% at 1 microM in MKN-45 cells. PRO-6E inhibits tumor growth in vivo and in vitro. PRO-6E induces cell apoptosis and induces cell arrest (Sturcture Note:(Blue: Cereblon ligand (HY-103596), Black: linker; Pink: ALK/c-Met inhibitor Crizotinib (HY-50878))[1].

O=C1C2=C(OCCCCCCCC(N3CCC(N4C=C(C5=CN=C(N)C(O[C@@H](C6=C(C(F)=CC=C6Cl)Cl)C)=C5)C=N4)CC3)=O)C=CC=C2C(N1C7C(NC(CC7)=O)=O)=O

-20°C,2°C to 8°C

12352200