Pro-MBP / htPAPP-A antibody [5H9]

GeneTex

Pro-MBP / htPAPP-A antibody [5H9]

9

This antibody is specific to proMBP subunit of the heterotetrameric complex of PAPP-A (htPAPP-A, consisting of PAPP-A subunits and proMBP subunits). It can be used to detect htPAPP-A when paired with another antibody which is specific for PAPP-A subunit.

ImmunoPrecipitation, Western Blot, ELISA

Research Use Only

Monoclonal

5H9

Unconjugated

PAPPA

pappalysin 1

ASBABP2; aspecific BCL2 ARE-binding protein 2; differentially placenta 1 expressed protein; DIPLA1; IGFBP-4ase; IGF-dependent IGFBP-4 protease; insulin-like growth factor-dependent IGF binding protein-4 protease; PAPA; PAPP-A; PAPPA1; pappalysin-1; pregnancy-associated plasma protein A, pappalysin 1

Mouse

IgG2b

Pappalysin-1

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017]

Human

2°C to 8°C

12352203