Proguanil hydrochloride [637-32-1]

TargetMol Chemicals

Proguanil hydrochloride [637-32-1]

9

637-32-1

Research Use Only

Proguanil hydrochloride

98.13%

C11H17Cl2N5

290.19

Proguanil hydrochloride (Chloroquanil) is a biguanide compound which metabolizes in the body to form cycloguanil, an anti-malaria agent.Upon hydrolysis, Proguanil hydrochloride is converted to its active cyclic triazine metabolite, cycloguanil, by a cytochrome P450 dependent reaction. Cycloguanil selectively inhibits the bifunctional dihydrofolate reductase-thymidylate synthase of plasmodium parasite, thereby disrupting deoxythymidylate synthesis and ultimately blocking DNA and protein synthesis in the parasite.

3 years

Cl.Clc1ccc(NC(=N)NC(=N)NC(C)C)cc1

-20°C

12352200