Prorenin antibody [6E2-B7]

GeneTex

Prorenin antibody [6E2-B7]

9

Recognises amino acid residues 16-29 (MPSIRESLKERGVD) of the prosegment of prorenin.

Western Blot, ELISA

Research Use Only

Monoclonal

6E2-B7

1 mg/ml

Unconjugated

REN

renin

ADTKD4; angiotensin-forming enzyme; angiotensinogenase; HNFJ2; renin; renin precursor, renal; RTD

Mouse

IgG1

Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]

Human

2°C to 8°C,-20°C or -80°C

12352203