PROTAC AR-NTD degrader 1
HY-149434
Overview
- SupplierMedChem Express
- Product NamePROTAC AR-NTD degrader 1 [3032601-92-3]
- Delivery Days Customer14
- CertificationResearch Use Only
- Molecular FormulaC41H47ClN6O7
- Molecular Weight771.30
- Scientific DescriptionPROTAC AR-NTD antagonist 1 (compound 18) is a small molecule protein-targeting chimera (PROTACs) targeting the Androgen Receptor AR-V7. PROTAC AR-NTD antagonist 1 antagonizes the N-terminal domain of AR (AR-NTD), degrades AR-V7 protein, and induces apoptosis in prostate cancer (PC) cells. The efficiencies of PROTAC AR-NTD antagonist 1 in degrading AR-V7 in VCaP cells were 62.2% (1 microM) and 71.1% (5 microM), respectively[1].
- SMILESO=C(N1)CCC(N2C(C3=CC=C(C=C3C2=O)NCCCN4N=NC(CCCCCOC5=CC=C(C(C)(C)C6=CC=C(OC[C@@H](CCl)O)C=C6)C=C5)=C4)=O)C1=O
- UNSPSC12131703