PROTAC BRAF-V600E degrader-1

MedChem Express

PROTAC BRAF-V600E degrader-1

10

Research Use Only

98.02

C48H54F2N10O10S

1001.07

PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with K d value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth [1] .

CCCS(=O)(NC1=CC=C(F)C(N2C=C(C3=CN=CN=C3)C4=NC(N(C5CCN(C(CCOCCOCCOCCNC6=CC=CC(C(N7C(CC8)C(NC8=O)=O)=O)=C6C7=O)=O)CC5)C)=CC=C42)=C1F)=O

-20°C,2°C to 8°C

12352200