PROTAC BRAF-V600E degrader-1

Biorbyt

PROTAC BRAF-V600E degrader-1

10

Research Use Only

C48H54F2N10O10S

1001.0652

PROTAC BRAF-V600E degrader-1 is a potent PROTAC BRAF-V600E degrader with Kd value of 2.4 nM and 2 nM for BRAF and BRAF-V600E, respectively. PROTAC BRAF-V600E degrader-1 degrades BRAF-V600E via the ubiquitin-proteasome system (UPS). PROTAC BRAF-V600E degrader-1 can inhibit melanoma cell growth.

S(C([H])([H])C([H])([H])C([H])([H])[H])(N([H])C1C([H])=C([H])C(=C(C=1F)N1C([H])=C(C2=C([H])N=C([H])N=C2[H])C2=C1C([H])=C([H])C(=N2)N(C([H])([H])[H])C1([H])C([H])([H])C([H])([H])N(C(C([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])OC([H])([H])C([H])([H])N([H])C2=C([H])C([H])=C([H])C3C(N(C(C=32)=O)C2([H])C(N([H])C(C([H])([H])C2([H])[H])=O)=O)=O)=O)C([H])([H])C1([H])[H])F)(=O)=O

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