PROTAC BRD4 Degrader-31

MedChem Express

PROTAC BRD4 Degrader-31

999

Research Use Only

C54H62ClN7O4S

940.63

PROTAC BRD4 Degrader-31 is a BRD4 PROTAC degrader with DC50 s of 164 and 80 nM at 4 h and 24 h, respectively. PROTAC BRD4 Degrader-31 potently degrades BRD4 in cells with long acting degradation kinetics[1]. Pink: BRD4 ligand (HY-78695); Blue: KLHDC2 ligand (HY-174218)

O=C(OC)C1=C2C(C(C3CCC4C3)C4C(C5=CC(OCCC6CCN(CC7CCN(C(C[C@@H]8N=C(C9=CC=C(Cl)C=C9)C(C(C)=C(C)S%10)=C%10N%11C8=NN=C%11C)=O)CC7)CC6)=CC=C5)N2)=CC=C1

12352200