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PROTAC BTK Degrader-1 [2801715-13-7]

HY-147943
MedChem Express
CAS Number2801715-13-7
Product group Chemicals
Estimated Purity98.87
Molecular Weight749.86
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Overview

  • Supplier
    MedChem Express
  • Product Name
    PROTAC BTK Degrader-1 [2801715-13-7]
  • Delivery Days Customer
    10
  • CAS Number
    2801715-13-7
  • Certification
    Research Use Only
  • Estimated Purity
    98.87
  • Molecular Formula
    C43H43N9O4
  • Molecular Weight
    749.86
  • Scientific Description
    PROTAC BTK Degrader-1 is a potent, selective and orally active PROTAC BTK degrader with an IC50 value of 34.51 nM and 64.56 nM for BTK WT and BTK-481S, respectively. PROTAC BTK Degrader-1 effectively reduces BTK protein levels and suppresses tumor growth[1]. PROTAC BTK Degrader-1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
  • SMILES
    O=C(N1)C(CCC1=O)N(C2=O)CC3=C2C=CC(C#CCN4CCC(CC4)N5CCC(CC5)N6N=C(C7=C(N=CN=C76)N)C8=CC=C(C=C8)OC9=CC=CC=C9)=C3
  • Storage Instruction
    2°C to 8°C
  • UNSPSC
    12131703