PROTAC CDK9 degrader-2 [2435721-30-3]

MedChem Express

PROTAC CDK9 degrader-2 [2435721-30-3]

10

2435721-30-3

Research Use Only

99.22

C39H36N6O10

748.74

PROTAC CDK9 degrader-2 (compound 11c) is a potent and selective CDK9 degrader based on PROTAC, with an IC50 of 17 microM in MCF-7 cell lines. Natural product Wogonin (CDK ligand) binds ubiquitin E3 ligase Cereblon (CRBN) via a linker to form PROTAC[1].

O=C(C=C(C1=CC=CC=C1)O2)C3=C2C(OCC4=CN(CCCCCCCC(NC5=C(C(N(C6C(NC(CC6)=O)=O)C7=O)=O)C7=CC=C5)=O)N=N4)=C(O)C=C3O

2°C to 8°C

12352200